He then starred in his first American film, The Guru, where he played Ramu Gupta, an Indian dance teacher who moves to America to be a star. Mistry next starred in the British comedy The Truth About Love.
Mistry was born to an Indian father and a Catholic Irish mother. He went to St James' Catholic High in Cheadle Hulme, Stockport from 1985 - 1988 before his family relocated to Cardiff where he attended Radyr Comprehensive School. He then trained at the Birmingham School of Acting. He has been married since 2001. He and his wife Meg have one child.
In Summer of 2007, Jimi started filming for the new E4 teen drama, Nearly Famous. The show subsequently began airing in November 2007.